dc.contributor.author | Longarzo, María L. | |
dc.contributor.author | Vázquez, Romina F. | |
dc.contributor.author | Bellini, María J. | |
dc.contributor.author | Zamora, Ricardo A. | |
dc.contributor.author | Redondo-Morata, Lorena | |
dc.contributor.author | Giannotti, Marina I. | |
dc.contributor.author | Oliveira, Osvaldo N. | |
dc.contributor.author | Fanani, María L. | |
dc.contributor.author | Mate, Sabina M. | |
dc.date.accessioned | 2024-07-09T17:52:41Z | |
dc.date.available | 2024-07-09T17:52:41Z | |
dc.date.issued | 2024-07-19 | |
dc.identifier.citation | Longarzo, M. L., Vázquez, R. F., Bellini, M. J., Zamora, R. A., Redondo-Morata, L., Giannotti, M. I., ... & Maté, S. M. (2024). Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes. iScience, 110362. | es |
dc.identifier.uri | http://hdl.handle.net/11086/552643 | |
dc.description | Impact Factor: 0.8 | es |
dc.description.abstract | A deficiency in omega-3 fatty acids (ω3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided ω3 FAs as a supplement to spontaneously hypertensive rats (SHR+ ω3). Our focus was on examining the impact of dietary supplementation on the physicochemical properties of the brain-cell membranes. Significant increases in ω3 levels in the cerebral cortex of SHR+ ω3 were observed, leading to alterations in brain lipid membranes molecular packing, elasticity, and lipid miscibility, resulting in an augmented phase disparity. Results from synthetic lipid mixtures confirmed the disordering effect introduced by ω3 lipids, showing its consequences on the hydration levels of the monolayers and the organization of the membrane domains. These findings suggest that dietary ω3 FAs influence the organization of brain membranes, providing insight into a potential mechanism for the broad effects of dietary fat on brain health and disease. | es |
dc.language.iso | eng | es |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Membrane architecture | es |
dc.subject | Neuroscience | es |
dc.subject | Cell biology | es |
dc.title | Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes | es |
dc.type | article | es |
dc.description.version | info:eu-repo/semantics/publishedVersion | es |
dc.description.fil | Fil: Longarzo, María L. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata, Argentina. | es |
dc.description.fil | Fil: Vázquez, Romina F. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata, Argentina. | es |
dc.description.fil | Fil: Bellini, María J. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata, Argentina. | es |
dc.description.fil | Fil: Zamora, Ricardo A. The Barcelona Institute of Science and Technology. Institute for Bioengineering of Catalonia, Spain. | es |
dc.description.fil | Fil: Zamora, Ricardo A. Universidad de Talca. Vicerrectoría Académica. Instituto de Investigación Interdisciplinaria, Chile. | es |
dc.description.fil | Fil: Zamora, Ricardo A. Universidad de Talca. Facultad de Ingeniería. Centro de Bioinformática, Simulación y Modelado, Chile. | es |
dc.description.fil | Fil: Redondo-Morata, Lorena. Universite´ de Lille. Institut Pasteur de Lille. Center for Infection and Immunity of Lille, France. | es |
dc.description.fil | Fil: Giannotti, Marina I. The Barcelona Institute of Science and Technology. Institute for Bioengineering of Catalonia, Spain. | es |
dc.description.fil | Fil: Giannotti, Marina I. Centro de Investigación Biomédica en Red en el área temática de Bioingeniería, Biomateriales y Nanomedicina, Spain. | es |
dc.description.fil | Fil: Giannotti, Marina I. University of Barcelona. Department of Materials Science and Physical Chemistry, Spain. | es |
dc.description.fil | Fil: Oliveira, Osvaldo N. Jr. Universidad de São Paulo. São Carlos Institute of Physics, Brazil. | es |
dc.description.fil | Fil: Fanani, María L. Universidad Nacional de Córdoba, Facultad de Cs. Químicas Departamento de Química Biológica Raquel Caputto, Argentina. | es |
dc.description.fil | Fil: Fanani, María L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica de Córdoba, Argentina. | es |
dc.description.fil | Fil: Mate, Sabina M. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata, Argentina. | es |
dc.journal.city | Massachusetts | es |
dc.journal.country | Estados Unidos | es |
dc.journal.editorial | Cell Press | es |
dc.journal.number | 7, art.110362 | es |
dc.journal.title | iScience | es |
dc.journal.volume | Volume 27 | es |
dc.identifier.eissn | 2589-0042 | |
dc.identifier.url | https://www.cell.com/iscience/fulltext/S2589-0042(24)01587-6#%20 | |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S2589004224015876 | |
dc.identifier.doi | https://doi.org/10.1016/j.isci.2024.110362 | |
dc.contributor.orcid | https://orcid.org/0000-0002-8779-3503 | es |
dc.contributor.orcid | https://orcid.org/0000-0002-7707-7482 | es |
dc.contributor.orcid | https://orcid.org/0000-0002-6254-8261 | es |
dc.contributor.orcid | https://orcid.org/0000-0002-5399-5860 | es |
dc.contributor.orcid | https://orcid.org/0000-0002-9495-124X | es |