Artículos
Recent Submissions
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3D printed scaffolds as delivery devices for nanocrystals: A proof of concept loading Atorvastatin with enhanced properties for sublingual route of administration
(2024-08-15)Increasing the solubility of drugs is a recurrent objective of pharmaceutical research, and one of the most widespread strategies today is the formulation of nanocrystals (NCs). Beyond the many advantages of formulating ... -
Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain
(2024-06-10)We synthesized two new gemini analogues, UG-480 and UG-481, that incorporate a modified longer side chain containing a cyclopropane group. The evaluation of the bioactivities of the two gemini analogues indicated that the ... -
Quantification of rifampicin loaded into inhaled polymeric nanoparticles by reversed phase high-performance liquid chromatography in pulmonary nonphagocytic cellular uptake
(2024-03-28)Rifampicin is an antibiotic effective against both Gram-negative and Gram-positive bacteria and is commonly used as a first-line treatment for tuberculosis caused by Mycobacterium tuberculosis. In this study, a reversed-phase ... -
Exploring the Phytochemical Composition and the Bioactive Properties of Malbec and Torrontés Wine Pomaces from the Calchaquíes Valleys (Argentina) for Their Sustainable Exploitation
(2024-06-07)Hydroalcoholic extracts from Malbec and Torrontés wine pomaces (Vitis vinifera L.) originating from the high-altitude vineyards of Argentina’s Calchaquí Valleys were characterized. Total phenolics, hydroxycinnamic acids, ... -
Editorial: Lithium metal anode protection
(Edited and reviewed by: Sheng S. Zhang, United States Army Research Laboratory, United States, 2024-07-16)Lithium metal has long been recognized as a promising candidate as an anode for nextgeneration high-energy-density batteries due to its high theoretical specific capacity and low electrode potential. However, the practical ... -
Optical Active Meta-Surfaces, -Substrates, and Single Quantum Dots Based on Tuning Organic Composites with Graphene
(2024-07-02)In this communication, the design and fabrication of optical active metamaterials were developed by the incorporation of graphene and joining it to different substrates with variable spectroscopical properties. It focuses ... -
Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis
(Academic Editor: Vivek Verma, 2024-03-22)Polyelectrolyte–drug complexes are interesting alternatives to improve unfavorable drug properties. Vancomycin (VAN) is an antimicrobial used in the treatment of methicillin-resistant Staphylococcus aureus pulmonary ... -
Synergistic bactericidal combinations between gentamicin and chitosan capped ZnO nanoparticles: A promising strategy for repositioning this first-line antibiotic
(2024-02-15)Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore the synergistic effects of zinc oxide nanoparticles (ZnO NPs) ... -
Intracellular Streptococcus pneumoniae develops enhanced fluoroquinolone persistence during influenza A coinfection
(2024-07-05)Streptococcus pneumoniae is a major pathogen responsible for severe complications in patients with prior influenza A virus (IAV) infection. We have previously demonstrated that S. pneumoniae exhibits increased intracellular ... -
Microbiota at the cross road of diet and health: how dietary fats shape bacterial land-scape and influence global health
(2024-07-08)Host-gut microbiota (GM) interactions play a pivotal role in shaping the delicate balance between health and disease within the human body. The impact of dietary factors, specifically high fat content diets on GM composition ... -
Octopamine is required for successful reproduction in the classical insect model, Rhodnius prolixus
(Wolfgang Blenau, University of Leipzig. Faculty of Life Sciences: Universitat Leipzig Fakultat fur Lebenswissenschaften, GERMANY, 2024-07-12)In insects, biogenic amines function as neurotransmitters, neuromodulators, and neurohormones, influencing various behaviors, including those related to reproduction such as response to sex pheromones, oogenesis, oviposition, ... -
Exploring Scoring Function Space: Developing Computational Models for Drug Discovery
(2024-05-01)Background: The idea of scoring function space established a systems-level approach to address the development of models to predict the affinity of drug molecules by those interested in drug discovery. Objective: Our goal ... -
Hexacoordinated tin complexes catalyse imine hydrogenation with H2
(2024-02-16)Frustrated Lewis pair (FLP) hydrogenation catalysts predominantly use alkyl- and aryl-substituted Lewis acids (LA) that offer a limited number of combinations of substituents, limiting our ability to tune their properties ... -
Geometry-induced Bloch point domain wall in Permalloy conical frustum nanowires for advanced spintronics applications
(2024-04-29)In this study, we investigate the pseudo-static magnetic properties of Permalloy conical frustum nanowires using micromagnetic simulations. We thoroughly examine how both the major and minor radii influence the magnetic ... -
A multicriteria GIS-based approach for mapping biomass agricultural residues availability for biopower plants
(2024-01-24)The development of accurate bioenergetic models, that simulate scenarios for decision making and policy planning contributions, has become a necessity in the actual climate crisis context. The objective of this work is to ... -
Palladium nanoparticles for the synthesis of phenanthridinones and benzo[c]chromenes via C–H activation reaction
(2024-06-11)In the present work, derivatives of phenanthridine-6(5H)-ones and benzo[c]chromenes were efficiently prepared through an intramolecular C–H bond functionalization reaction catalyzed by photochemically synthesized Pd-PVP ... -
Rational Design of 2D Supramolecular Networks Switchable by External Electric Fields
(2024-01-23)The reversible formation of hydrogen bonds is a ubiquitous mechanism for controlling molecular assembly in biological systems. However, achieving predictable reversibility in artificial two-dimensional (2D) materials remains ... -
Bay-Substitution of Perylene Bisimides with Bidentate Nucleophiles: The Case of Aryloxide Anions
(2024-01-25)In this study, we delve into the regioselectivity of nucleophilic reactions involving brominated perylene bisimides (PBIs) and various bidentate aryloxide anions, previously associated with an SRN1 mechanism. We present ... -
Arabidopsis DNA glycosylase MBD4L improves recovery of aged seeds
(Society for Experimental Biology, 2024-06-04)DNA glycosylases initiate the base excision repair (BER) pathway by catalyzing the removal of damaged or mismatched bases from DNA. The Arabidopsis DNA glycosylase methyl-CpG-binding domain protein 4 like (MBD4L) is a ... -
Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes
(2024-07-19)A deficiency in omega-3 fatty acids (ω3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided ω3 FAs as a supplement to spontaneously ...