Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes
Date
2024-07-19Author
Longarzo, María L.
Vázquez, Romina F.
Bellini, María J.
Zamora, Ricardo A.
Redondo-Morata, Lorena
Giannotti, Marina I.
Oliveira, Osvaldo N.
Fanani, María L.
Mate, Sabina M.
ORCID
https://orcid.org/0000-0002-8779-3503https://orcid.org/0000-0002-7707-7482
https://orcid.org/0000-0002-6254-8261
https://orcid.org/0000-0002-5399-5860
https://orcid.org/0000-0002-9495-124X
Metadata
Show full item recordAbstract
A deficiency in omega-3 fatty acids (ω3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided ω3 FAs as a supplement to spontaneously hypertensive rats (SHR+ ω3). Our focus was on examining the impact of dietary supplementation on the physicochemical properties of the brain-cell membranes. Significant increases in ω3 levels in the cerebral cortex of SHR+ ω3 were observed, leading to alterations in brain lipid membranes molecular packing, elasticity, and lipid miscibility, resulting in an augmented phase disparity. Results from synthetic lipid mixtures confirmed the disordering effect introduced by ω3 lipids, showing its consequences on the hydration levels of the monolayers and the organization of the membrane domains. These findings suggest that dietary ω3 FAs influence the organization of brain membranes, providing insight into a potential mechanism for the broad effects of dietary fat on brain health and disease.
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Longarzo, M. L., Vázquez, R. F., Bellini, M. J., Zamora, R. A., Redondo-Morata, L., Giannotti, M. I., ... & Maté, S. M. (2024). Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes. iScience, 110362.
Other links
https://www.cell.com/iscience/fulltext/S2589-0042(24)01587-6#%20https://www.sciencedirect.com/science/article/pii/S2589004224015876
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