Synthesis of a new chiral bis-arsine ligand based on natural carbohydrates
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Date
2013Author
Parajón Puenzoa, Sol C.
Arata Badano, Joaquín
Lopez Vidal, Martin G.
Varela, Oscar
Martín, Sandra E.
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Transition-metal-catalyzed asymmetric allylic substitutions have become one of the most powerful tools for asymmetric C−C bond formation.1 Chiral diphosphine ligands have been some of the largest classes of ligands used in asymmetric substitutions.
Trost developed the chiral ligand, which played a crucial role in the improvement of Pdcatalyzed asymmetric substitutions.2 Based on the Trost modular ligand (TML) system 3 a family of ligands has been prepared. We recently reported the synthesis and application of the novel chiral bis-arsine ligand 2 derived from TML.