dc.contributor.author | Oladele, Johnson O. | |
dc.contributor.author | Ajayi, Ebenezer Idowu O. | |
dc.contributor.author | Oyeleke, Oyedotun M. | |
dc.contributor.author | Oladele, Oluwaseun T. | |
dc.contributor.author | Olowookere, Boyede D. | |
dc.contributor.author | Adeniyi, Boluwaji M. | |
dc.contributor.author | Oyewole, Olu I. | |
dc.contributor.author | Oladiji, Adenike T. | |
dc.date.accessioned | 2021-08-25T02:24:22Z | |
dc.date.available | 2021-08-25T02:24:22Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier.issn | 2405-8440 | |
dc.identifier.uri | http://hdl.handle.net/11086/19894 | |
dc.identifier.uri | https://www.cell.com/heliyon/fulltext/S2405-8440(20)31740-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844020317400%3Fshowall%3Dtrue | |
dc.description.abstract | Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease. | es |
dc.language.iso | eng | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | SARS-CoV-2 | es |
dc.subject | Antivirals | es |
dc.subject | COVID-19 | es |
dc.subject | Phytochemicals | es |
dc.subject | Coronavirus | es |
dc.subject | Medicinal plants | es |
dc.subject | Biochemistry | es |
dc.subject | Epidemiology | es |
dc.subject | Food science | es |
dc.subject | Health sciences | es |
dc.subject | Pathophysiology | es |
dc.subject | Toxicology | es |
dc.subject | Phytochemistry | es |
dc.subject | Evidence based medicine | es |
dc.title | A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants | es |
dc.type | article | es |
dc.description.version | publishedVersion | es |
dc.description.fil | Fil: Oladele, Johnson O. Kings University; Nigeria. | es |
dc.description.fil | Fil: Ajayi, Ebenezer Idowu O. Osun State University; Nigeria. | es |
dc.description.fil | Fil: Ajayi, Ebenezer Idowu O. Universidad Nacional de Córdoba. Rectorado; Argentina. | es |
dc.description.fil | Fil: Ajayi, Ebenezer Idowu O. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra.; Argentina. | es |
dc.description.fil | Fil: Oyeleke, Oyedotun M. Kings University; Nigeria. | es |
dc.description.fil | Fil: Oladele, Oluwaseun T. Osun State University; Nigeria. | es |
dc.description.fil | Fil: Olowookere, Boyede D. Kings University; Nigeria. | es |
dc.description.fil | Fil: Adeniyi, Boluwaji M. Benue State University; Nigeria. | es |
dc.description.fil | Fil: Oyewole, Olu I. Osun State University; Nigeria. | es |
dc.description.fil | Fil: Oladiji, Adenike T. University of Ilorin; Nigeria. | es |
dc.journal.city | Londres | es |
dc.journal.country | Reino Unido | es |
dc.journal.editorial | Elsevier | es |
dc.journal.number | 9 | es |
dc.journal.pagination | 1-17 | es |
dc.journal.title | Heliyon | es |
dc.journal.volume | 6 | es |