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RNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans

dc.contributor.authorVarela, Gonzalo M.
dc.contributor.authorGarcía, Beatriz A.
dc.contributor.authorStroppa, María M.
dc.date.accessioned2024-07-12T17:03:22Z
dc.date.available2024-07-12T17:03:22Z
dc.date.issued2024-04
dc.identifier.citationVarela, G. M., García, B. A., & Stroppa, M. M. (2024). RNA interference of NADPHcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestans. Acta Tropica, 252, 107149.es
dc.identifier.urihttp://hdl.handle.net/11086/552733
dc.description.abstractThe enzyme NADPH-cytochrome P450 reductase (CPR) plays a central role in cytochromes P450 activity. Gene expression analysis of cytochromes P450 and CPR in deltamethrin-resistant and susceptible populations revealed that P450s genes are involved in the development of insecticide resistance in Triatoma infestans. To clarify the role of cytochromes P450 in insecticide resistance, it was proposed to investigate the effect of CPR gene silencing by RNA interference (RNAi) in a pyrethroid resistant population of T. infestans. Silencing of the CPR gene showed a significant increase in susceptibility to deltamethrin in the population analysed. This result support the hypothesis that the metabolic process of detoxification mediated by cytochromes P450 contributes to the decreased deltamethrin susceptibility observed in the resistant strain of T. infestans.es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChagas diseasees
dc.subjectTriatoma infestanses
dc.subjectPyrethroid resistancees
dc.subjectCytochrome P450es
dc.subjectNADPH cytochrome P450 reductasees
dc.titleRNA interference of NADPHsingle bondcytochrome P450 increased deltamethrin susceptibility in a resistant strain of the Chagas disease vector Triatoma infestanses
dc.typearticlees
dc.description.versioninfo:eu-repo/semantics/publishedVersiones
dc.description.filFil: Varela, Gonzalo Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina.es
dc.description.filFil: Varela, Gonzalo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.es
dc.description.filFil: García, Beatriz Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.es
dc.description.filFil: García, Beatriz Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina.es
dc.description.filFil: Stroppa, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina.es
dc.description.filFil: Stroppa, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina.es
dc.journal.countryEstados Unidoses
dc.journal.editorialElsevieres
dc.journal.number107149es
dc.journal.titleActa Tropicaes
dc.journal.volume252es
dc.identifier.eissn1873-6254


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International