Salivary proinflamatory cytokines IL-1β, IL-6 and TNF decrease with age
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Date
2022-04-26Author
Costantino, Evangelina
Castell, Sofía Daiana
Harman, María Florencia
Pistoresi- Palencia, María Cristina
Actis, Adriana Beatriz
ORCID
https://orcid.org/0000-0003-1428-9194https://orcid.org/0000-0003-1232-4638
https://orcid.org/0000-0002-0355-5154
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Show full item recordAbstract
Objective: to analyze salivary concentrations interleukin-1β (IL-1β), 6 (IL-6) and tumor necrosis factor
(TNF) according to age in healthy subjects to determine baseline inflammatory state of the oral mucosa in
elderly subjects, who are at higher risk of developing inflammation-related diseases.
Materials and methods: sixty-four healthy volunteers were divided into groups according to age: 20-39
(G1; n=20); 40-59 (G2; n=24); 60-80 years (G3; n=20). Their stomatognathic system and periodontal
status were assessed; consumption of food sources of fatty acids (FA) was evaluated using a validated
food frequency questionnaire. IL-1β, IL-6, and TNF salivary levels were determined (ELISA) in mixed
unstimulated saliva. Kruskal Wallis and Spearman’s correlation tests were applied (p<0.05).
Results: salivary IL-1β and TNF levels were lower in G2 (p=0.001) and G3 (p<0.001) than in G1; IL-6
levels were lower in G3 than in G2 and G1 (p= <0.001). IL-1β showed the highest concentration in all
groups (p<0.001). No statistically significant differences in salivary cytokine levels were observed on sex
in any of the groups. Associations were observed between salivary cytokines and consumption of some
foods containing FA.
Conclusion: salivary concentration of proinflammatory cytokines decreased with age. It could be
influenced by ageing-related changes. In addtition, the baseline inflammatory state of the oral mucosa
would appear to be influenced by dietary intake of sources of anti-inflammatory FA.
Clinical relevance: the knowledge about inflammatory state of the oral mucosa, as determined by
salivary cytokine concentrations, could be useful for understanding and prevention of developing
inflammation-related diseases.
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