Kinetic study of the stereoselectivity reduction of acetophenone promoted by a strain of Geotrichum spp
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Date
2015Author
Decarlini, M. F.
Vázquez, A. M.
Aimar, M. L.
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Nowadays, biocatalytic stereoselective reduction of prochiral ketones is one of the
most important methodologies in organic synthesis for the preparation of chiral
alcohols. These enantiomerically pure alcohols are very important because they
are key precursors in the obtaining of pharmaceutical compounds. Recently, a
screening on fifty six strains of bacteria and fungi was made for our team toidentify
microorganisms capable of performing the stereoselective reduction of
acetophenone (AP) to 1-phenylethanol (1-PE). From this study a strain of
Geotrichum spp.has been isolated and characterized, and this yeast has presented
anexcellent conversion (>99%) and stereoselectivity (>99.9 e.e.%) in the
preparation of (R)-1-PE from AP.