Determination of Streptococcus sp. and Candida albicans in the oral cavity of patients undergoing bone marrow transplantation
Date
2021-12-31Author
Bachmeier, Evelin
Migueles Goitea, María Elena
Weitz, Fernando Martín
Jarchum, Sol
Jarchum, Gustavo
Brunotto, Mabel Noemí
Mazzeo, Marcelo Adrián
ORCID
http://orcid.org/0000-0001-5900-8603http://orcid.org/0000-0002-5377-3811
http://orcid.org/0000-0003-2709-5436
http://orcid.org/0000-0001-8895-9424
http://orcid.org/0000-0002-9235-7941
http://orcid.org/0000-0001-6253-9317
http://orcid.org/0000-0001-8010-1079
http://orcid.org/0000-0002-7950-613X
Metadata
Show full item recordAbstract
Chemotherapy can lead to an imbalance in theecosystem of the oral cavity, allowing the development of mucositis in theimmunosuppression phase due to interaction with microbial agents. Theobjective of this study was to identify bacterial and fungal species thatcontribute to oral complications in patients undergoing marrow translantationand compare their susceptibility to various antimicrobial agentsbefore and during the immunosuppression period. Material and Methods:This observational-longitudinal study was performed on 18 patientsundergoing bone marrow transplantation from the Oncohematology Serviceof Sanatorio Allende (2018/2019), with buccal mucosa swabs beforetreatment (I) and mid-stage (M), fourteen days after transplantation. Thesamples were cultured in selective media for Streptococcus and fungal speciesand a susceptibility study was performed on Müller Hinton agar. Results: At(I), 82.30% of patients were found to be positive for Streptococcus mutans,11.30% for Streptococcus salivarius, 5.50% for Streptococcus sobrinus and9.40% grew mixed commensal microorganisms. At (M), 96.60% were positivefor Streptococcus mutans and 23.10% for Streptococcus salivarius, without anygrowth of Streptococcus sobrinus or mixed microorganisms. In (I), a 27.00%incidence of Candida albicans was observed, while in (M) the incidence was73.00%. The antibiotics to which the microorganisms were most sensitivein (I) were vancomycin (88.80%), amikacin (83.30%), amoxicillin + clavulanicacid (78.00%), ciprofloxacin (77.75%) and azithromycin (66.60%). In (M)sensitivity to amikacin was 92.30%, vancomycin, 76.90%; amoxicillin +clavulanic acid, 38.50%; azithromycin, 23.10%; and ciprofloxacin, 15.40%.A statistically significant prevalence of Streptococcus mutans was observedin comparison to other species. Conclusion: During the immunosuppressionperiod, there was a significant increase in Candida albicans. The antibiotics towhich the bacteria were most sensitive were amikacin and, to a lesser extent,vancomycin, showing significant resistance to ciprofloxacin, azithromycinand amoxicillin + clavulanic acid.