Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
Abstract
The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent
an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping
functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox
couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin,
SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS
species between them.