Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.
Date
2014Author
Morelatto, R.
Itoiz, M.E.
Guiñazú, N.
Piccini, D.
Gea, S.
López de Blanc, S.
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Show full item recordAbstract
The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in
normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas,
which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2
expression at the histologically normal margins of OSCC.
Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed.
Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry.
Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed.
The Chi-squared test was applied.
Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control
group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and
tobacco and/or alcohol consumption and salivary nitrate and nitrite was found.
Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field
cancerization before the appearance of potentially malignant morphological changes.
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