dc.contributor.author | Bono, Alejandra | |
dc.contributor.author | Zárate, Ana María | |
dc.contributor.author | Don, Julieta | |
dc.contributor.author | Barra, José Luis | |
dc.contributor.author | Brunotto, Mabel | |
dc.date.accessioned | 2022-02-22T13:02:55Z | |
dc.date.available | 2022-02-22T13:02:55Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1368-8375 | |
dc.identifier.uri | http://hdl.handle.net/11086/22697 | |
dc.description.abstract | Introduction
The greatest challenge is to predict which oral leukoplakia (OL) will be able to progress to oral squamous cell carcinoma.
Purpose
Generally, the systematic reviews and meta-analysis of polymorphisms are focused in genes related to unique cellular process; in this work, our goal was to identify studied genes in last decade and to know which ones are related to the risk of developing OL.
Method
Eligible gene/polymorphism studies were identified by electronic searches. Individual participant data of 2054 Oral Leukoplakia and 3493 controls from 16 genetic studies were analyzed, yielding adjusted (tobacco, gender, age and alcohol) odds ratios (OR) and 95% confidence intervals (CIs) comparing cases with controls.
Results
The following genes/polymorphisms were seen to have significant association with increased risk of OL: CYPA1 (m1/m2), XDP (Gln/Gln), GSTM1 (null), and P53 (intron 6). In contrast, COX-2 (exon 10), P53 (intron 3), XRCC3 (GG), and PRKDC (rs7003908) polymorphisms are associated with a diminished risk of OL.
Conclusions
According to the results of this work, we conclude that all genotypes are heterozygous or homozygous for the polymorphic variants; and the people with genotypes CYP1A1 m1/m2, XDP Gln/Gln, GSTM1 null, P53 intron 6, XRCC3 rs861539, COX2 -765 have high risk of presented OL, and therefore they are more exposed to oral cancer risk. | es |
dc.description.uri | http://www.journals.elsevier.com/oral-oncology/ | |
dc.format.medium | Electrónico y/o Digital | |
dc.language.iso | eng | es |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Revisión sistemática | es |
dc.subject | Leucoplasia bucal | es |
dc.subject | Carcinoma de células escamosas | es |
dc.title | Risk Polymorphisms in oral Leukoplakia: a Systematic Review | es |
dc.type | conferenceObject | es |
dc.description.fil | Fil: Bono, Alejandra Liliana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Periodoncia A; Argentina. | es |
dc.description.fil | Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. | es |
dc.description.fil | Fil: Don, Julieta. Universidad Nacional de Córdoba. Facultad de Odontología. Departamento de Biología Bucal; Argentina. | es |
dc.description.fil | Fil: Barra, José Luis . Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina. | es |
dc.description.fil | Fil: Barra, José Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica; Argentina. | es |
dc.description.fil | Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. | es |
dc.description.field | Epidemiología | |
dc.conference.city | San Pablo | |
dc.conference.country | Brasil | |
dc.conference.editorial | Elsevier | |
dc.conference.event | 5th congress IAOO | |
dc.conference.eventcountry | Brasil | |
dc.conference.eventdate | 2015-7 | |
dc.conference.journal | International Academy of Oral Oncology | |
dc.conference.publication | Revista | |
dc.conference.work | Resumen | |
dc.conference.type | Congreso | |