In vitro modifications on functional activity of mice sperm induced by the addition of ghrelin
Modificaciones inducidas in vitro por ghrelina sobre la actividad funcional espermática murina.
Torres, Pedro Javier
De Loredo, Nicolás
Vincenti, Laura María
Fiol de Cuneo, Marta
Martini, Ana Carolina
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Ghrelin (Ghr) is a peptide that modulates reproductive physiology, linking reproduction with energy balance. The expression of the peptide and its receptor has been reported in testis, prostate and sperm; the presence of Ghr in seminal plasma has also been informed. The aim of our study was to evaluate the in vitro effects of different doses of Ghr (10-7M and 10-9M), with or without the co-administration of an antagonist (Ant: (D-Lys 3) GHRP-6, 10-5M) on sperm functional activity.