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dc.contributor.authorKembro, Jackeline Melissa
dc.contributor.authorCortassa, Sonia
dc.contributor.authorLloyd, David
dc.contributor.authorSollott, Steven
dc.contributor.authorAon, Miguel
dc.date.accessioned2020-12-07T14:20:42Z
dc.date.available2020-12-07T14:20:42Z
dc.date.issued2018-10-18
dc.identifier.citationKembro, J.M., Cortassa, S., Lloyd, D. et al. Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability. Sci Rep 8, 15422 (2018). https://doi.org/10.1038/s41598-018-33582-wes
dc.identifier.otherhttps://doi.org/10.1038/s41598-018-33582-w
dc.identifier.urihttp://hdl.handle.net/11086/17032
dc.description.abstractMitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the “edge” between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the “edge” mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.es
dc.language.isoenges
dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectMitochondriaes
dc.subjectBiophysicses
dc.subjectBiologia Moleculares
dc.subjectChaotic Dynamicses
dc.subjectRedox perturbationses
dc.subjectComplex Oscillatory Behaviores
dc.subjectLyapunov Exponentes
dc.subjectStrange Attractorses
dc.titleMitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stabilityes
dc.typearticlees
dc.description.versionpublishedVersiones
dc.description.filKembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.es
dc.description.filKembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.es
dc.description.filCortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos.es
dc.description.filLloyd, David. Cardiff University. School of Biosciences 1; Inglaterra.es
dc.description.filSollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos.es
dc.description.filSollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos.es
dc.journal.editorialNature Researches
dc.journal.titleScientific reportses


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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