dc.contributor.author | Kembro, Jackeline Melissa | |
dc.contributor.author | Cortassa, Sonia | |
dc.contributor.author | Lloyd, David | |
dc.contributor.author | Sollott, Steven | |
dc.contributor.author | Aon, Miguel | |
dc.date.accessioned | 2020-12-07T13:40:19Z | |
dc.date.available | 2020-12-07T13:40:19Z | |
dc.date.issued | 2018-09-26 | |
dc.identifier.citation | Kembro, Jackelyn Melissa; Cortassa, Sonia; Lloyd, David; Sollott, Steven; Aon, Miguel (2018): Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 mM. figshare. Dataset. https://doi.org/10.6084/m9.figshare.7117907.v1 | es |
dc.identifier.other | https://doi.org/10.6084/m9.figshare.7117907.v1 | |
dc.identifier.uri | http://hdl.handle.net/11086/17030 | |
dc.description.abstract | Analytical methods. Numerical integration of the ME-R model equations was performed with MatCont 2.4 in MATLAB 7.1, until steady-state solutions were obtained (i.e., when the magnitude of each time derivative was -10). Time series with duration of at least 6e6 ms were constructed by numerical integration of model equations. To allow transient states to vanish, the system was computed during a time lapse of 2 e8 ms.All studies were performed using the parameter setting optimized in our previous work (Kembro et al. 2013. Biophys J 104(2):332-343; Kembro et al., 2014. Front Physiol 5:257), with ADPm = 0.01mM, i.e. consistent with energized mitochondria under state 4 respiration.
The two .txt file represents the time reference and the time series of variables output of the model, in order from left to right column: 1) Mitochondrial Ca+;2) Mitochondrial ADP; 3) Membrane potential; 4)Mitocondrial NADH; 5) Mitochondrial H+; 6) Mitochondrial Phosfate, Pi; 7) Isocitrate; 8) a-ketoglutarate; 9) Succinyl CoA; 10) Succinate; 11) Fumarate; 12) Malate; 13) Oxaloacetate; 14) NADPH; 15) Mitochondrial superoxide; 16) Extramitochondrial superoxide; 17) Mitochondrial hydrogen peroxide; 18) Extramitochondrial hydrogen peroxide; 19) Mitochondrial GSH; 20) Extramitochondrial GSH; 21)Mitochondrial GSSG; 22) Mitochondrial TrxSH2; 23) ExtramitochondrialTrxSH; 24)Mitochondrial PSSGm; 25) Extramitochondrial PSSG. | es |
dc.language.iso | spa | es |
dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Animal Physiology - Biophysics | es |
dc.subject | Animal Physiology - Systems | es |
dc.subject | Biophysics | es |
dc.subject | Mitochondria | es |
dc.subject | Mitochondria- bioenergetics model | es |
dc.subject | Oxidative stress effect | es |
dc.subject | Oxidative stress enzymes | es |
dc.title | Chaotic fluctuations in mitochondrial function under oxidative stress. SOD2 concentrations of 0.016 | es |
dc.type | dataSet | es |
dc.description.fil | Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. | es |
dc.description.fil | Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. | es |
dc.description.fil | Cortassa, Sonia. National Institutes of Health. NIH · NIA Intramural Research Program; Estados Unidos. | es |
dc.description.fil | Lloyd, David. Cardiff University. School of Biosciences 1; Inglaterra. | es |
dc.description.fil | Sollot, Steven. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. | es |
dc.description.fil | Aon, Miguel. Johns Hopkins University. Laboratory of Cardiovascular Science; Estados Unidos. | es |