Layered double hydroxides-indomethacin nanohybrids : intercalation, pH influence, stability and release properties
View/ Open
Date
2016Author
Mendieta, Silvia Nazareth
Oliva, Marcos Iván
Pérez, Celso Francisco
Reyes Nuñez, Patricio
Longhi, Marcela Raquel
Granero, Gladys Ester
Crivello, Mónica Elsie
ORCID
https://orcid.org/0000-0002-3781-1777https://orcid.org/0000-0002-3189-9886
https://orcid.org/0000-0003-2142-1675
https://orcid.org/0000-0001-7463-9710
Metadata
Show full item recordAbstract
In this work, three pH values (8, 9 and 10) were studied for the insertion of Indomethacin (Indo) molecules into Layered Double Hydroxides (LDHs). The obtained results showed that the LDH materials have been a good storage for the drug. LDHs provide thermal stability with an increase in the thermal decomposition of the drug around 100°C more. Indo into LDHs exhibited higher photostability to UV light irradiation. In vitro drug release experiments in a phosphate buffer solution (pH = 7.4) have been carried out. The loading amount of intercalated Indo was increased to 66 % at pH 8, and showed a profile of sustained release of 97 % in 8h. The release profiles were fitted by mathematical models, which describe various kinetic models that served to investigate the drug release mechanism, being the Bhaskar kinetics model the most appropriate. The results showed that the nanohybrids can be used as an effective drug delivery system.
xmlui.dri2xhtml.METS-1.0.item-citation
Mendieta, S., Oliva, M., Pérez, C., Reyes Nuñez, P., Longhi, M., Granero, G. y Crivello, M. (2016). Layered double hydroxides-indomethacin nanohybrids : intercalation, pH influence, stability and release properties. World Journal of Pharmaceutical Sciences, 4 (3), 276-288.