Browsing by Author "Cabrera Zapata, Lucas Ezequiel"
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Activation of erk1/2 and axogenesis induced by estradiol depend on different calcium pools in male rat hypothalamic neurons in vitro
Cabrera Zapata, Lucas Ezequiel; Cambiasso, María Julia (2016)Estrogens generate a wide diversity of rapid “non-classical” effects which occur in a range from some seconds to few minutes (Arevalo et al., 2012), including the triggering of Ca2+ signals (Wong et al., 2012) and the ... -
Early sex differences in histone methyl transferase EZH2 expression in developing hypothalamus of the mouse brain
Villarreal, Macarena; Bigarani, Rocío; Sosa, Camila; Cabrera Zapata, Lucas Ezequiel; Cisternas, Carla Daniela; Cambiasso, María Julia (2022)In mammals, the primary agents causing phenotypic sex differences are encoded by sex chromosomes. Many of X-and Y-linked genes are epigenetic modifiers and pivotal evidence in past 7 years implicates epigenetic mechanisms ... -
Sex differences in gene expression of X-linked histone demethylase Kdm6a in embryonic hypothalamic neurons
Cabrera Zapata, Lucas Ezequiel; Sosa, Camila; Cambiasso, María Julia (2018)Kdm6a and Kdm5c are histone demethylases that play an important role as epigenetic regulators of gene transcription by removing the di- and tri-methylation of Lys27 or Lys4 on histone H3 (H3K27me2/me3 - H3K4me2/me3). Both ... -
Sex differences in X-linked gene expression in embryonic hypothalamic neurons
Cabrera Zapata, Lucas Ezequiel; Cisternas, Carla Daniela; Cambiasso, María Julia (Sociedad Argentina de Investigación en Neurociencias, 2017)Although sex hormones are usually considered the main architects of sexual dimorphisms, recent studies have demonstrated that sex chromosomes can also induce sex differences in somatic gene expression in the absence of ...