dc.contributor.author | Villarreal, Macarena | |
dc.contributor.author | Bigarani, Rocío | |
dc.contributor.author | Sosa, Camila | |
dc.contributor.author | Cabrera Zapata, Lucas Ezequiel | |
dc.contributor.author | Cisternas, Carla Daniela | |
dc.contributor.author | Cambiasso, María Julia | |
dc.date.accessioned | 2024-03-25T15:05:23Z | |
dc.date.available | 2024-03-25T15:05:23Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | http://hdl.handle.net/11086/551243 | |
dc.description.abstract | In mammals, the primary agents causing phenotypic sex differences are encoded by sex chromosomes. Many of X-and Y-linked genes are epigenetic modifiers and pivotal evidence in past 7 years implicates epigenetic mechanisms as mediators in brain sexual differentiation. We have recently demonstrated that X‑linked histone H3K27 demethylase Kdm6a regulates sexually dimorphic differentiation of hypothalamic neurons through a direct regulation of Neurogenin 3. Kdm6a interacts with numerous epigenetic modifiers, such as histone methyltransferases (HMT), implying that both epigenetic marks could act together, influencing each other in a context-dependent manner, writing a histone crosstalk language. Since H3K27 methylation regulates Ngn3 we first evaluated the mRNA expression of the HMT enzymes EZH1/2 in the hypothalamus of male and female mice at embryonic day 15 by qPCR. We found sex specific expression of Ezh2, higher in males than in females (p = 0.01). We next used the Four Core Genotype Mouse Model to evaluate a direct regulation of sex chromosomes (XX vs XY) independently of gonadal type. No differences were observed between genotypes (p > 0.05). Our results suggest that early sex differences in Ezh2 enzyme could determine a sexually dimorphic crosstalk between posttranslational histone modifications acting on H3K27 residues during development. Current experiments are evaluating the effect of Ezh2 inhibition on Ngn3 expression in neuronal hypothalamic cultures. | es |
dc.description.uri | https://san2022.saneurociencias.org.ar | |
dc.format.medium | Electrónico y/o Digital | |
dc.language.iso | eng | es |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | sex chromosomes | es |
dc.subject | Hypothalamus | es |
dc.subject | Enhancer of Zeste Homolog 2 Protein | es |
dc.subject | Sex chromosomes | es |
dc.title | Early sex differences in histone methyl transferase EZH2 expression in developing hypothalamus of the mouse brain | es |
dc.type | conferenceObject | es |
dc.description.fil | Fil: Villarreal, Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. | es |
dc.description.fil | Fil: Bigarani, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. | es |
dc.description.fil | Fil: Sosa, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. | es |
dc.description.fil | Fil: Sosa, Camila. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. | es |
dc.description.fil | Fil: Cabrera Zapata, Lucas Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. | es |
dc.description.fil | Fil: Cabrera Zapata, Lucas Ezequiel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. | es |
dc.description.fil | Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular; Argentina. | es |
dc.description.fil | Fil: Cisternas, Carla Daniela. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Fisiología Animal; Argentina. | es |
dc.description.fil | Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. | es |
dc.description.fil | Fil: Cambiasso, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular B; Argentina. | es |
dc.description.fil | Fil: Cambiasso, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. | es |
dc.description.field | Bioquímica y Biología Molecular (ídem 3.1.10) | |
dc.conference.city | Buenos Aires | |
dc.conference.country | Argentina | |
dc.conference.editorial | Sociedad Argentina de Investigación en Neurociencias (SAN) | |
dc.conference.event | XXXVII SAN Annual Congress | |
dc.conference.eventcity | Buenos Aires | |
dc.conference.eventcountry | Argentina | |
dc.conference.eventdate | 2022-9 | |
dc.conference.institution | Sociedad Argentina de Investigación en Neurociencias (SAN) | |
dc.conference.journal | Libro de resúmenes de la XXXVII Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias | |
dc.conference.publication | Libro | |
dc.conference.work | Resumen | |
dc.conference.type | Congreso | |