dc.contributor.author | Grosso, Carla Gisela | |
dc.contributor.author | Stroppa, María Mercedes | |
dc.contributor.author | García, Beatríz Alicia | |
dc.contributor.author | Varela, Gonzalo Matías | |
dc.date.accessioned | 2023-12-06T18:30:51Z | |
dc.date.available | 2023-12-06T18:30:51Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0002-9637 | |
dc.identifier.uri | http://hdl.handle.net/11086/550125 | |
dc.description | 7 p. | es |
dc.description.abstract | Pyrethroid resistance has been detected in Triatoma infestans (Hemiptera: Reduviidae), which was atributed to target site insensitivity and increased oxidative metabolism of the insecticide by cytochrome P450s. NADPH cytochrome P450 reductase (CPR) plays an essential role in transferring electrons from NADPH to the P450-substrate complex. In this study, the full length CPR cDNA of T. infestans was isolated and gene expression was determined by quantitative PCR. The open reading frame is 2046 bp long, encoding a protein of 682 amino acids. Amino acid sequence analysis indicates that the T. infestans CPR and the putative Rhodnius prolixus and Triatoma dimidiata CPRs, present conserved ligand-binding domains. Congruently with a previous study of our laboratory, in which the expression of three cytochrome P450 genes (CYP4EM7, CYP3085B1, and CYP3092A6 genes) was induced by deltamethrin, the levels of T. infestans CPR mRNA were up-regulated in the fat body of fifth instar nymphs after topical application of deltamethrin. Besides, as it was observed in the CYP4EM7 gene, it was detected overexpression of the CPR gene in the most resistant strain of T. infestans included in the study. These results suggest that CPR plays an essential role in P450-mediated resistance of T. infestans to insecticides. | es |
dc.format.medium | Impreso | |
dc.language.iso | eng | es |
dc.publisher | American Society of Tropial Medicine and Hygiene | es |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | NADPH CYTOCHROME P450 REDUCTASE GENE | es |
dc.subject | TRIATOMA INFESTANS | es |
dc.subject | CHAGAS DISEASE VECTOR | es |
dc.title | cDNA isolation and expression of nicotinamide adenine dinucleotide phosphate-dependent cytochrome P450 reductase gene in the Chagas disease vector Triatoma infestans | es |
dc.type | article | es |
dc.description.version | info:eu-repo/semantics/publishedVersion | es |
dc.description.fil | Fil: Grosso, Carla Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. | es |
dc.description.fil | Fil: Grosso, Carla Gisela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. | es |
dc.description.fil | Fil: Stroppa, María Mercedes. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. | es |
dc.description.fil | Fil: Varela, Gonzalo Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. | es |
dc.description.fil | Fil: Varela, Gonzalo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. | es |
dc.description.fil | Fil: Stroppa, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. | es |
dc.description.fil | Fil: García, Beatriz Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. | es |
dc.description.fil | Fil: García, Beatriz Alicia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bioquímica y Biología Molecular; Argentina. | es |
dc.journal.city | Arlington | es |
dc.journal.country | Estados Unidos | es |
dc.journal.number | 3 | es |
dc.journal.pagination | 710-716 | es |
dc.journal.referato | Con referato | |
dc.journal.title | American Journal of Tropical Medicine and Hygiene | es |
dc.journal.volume | 98 | es |
dc.description.field | Bioquímica y Biología Molecular (ídem 3.1.10) | |
dc.identifier.eissn | 1476-1645 | |