Differential effects of tianeptine on dorsal hippocampal volume in rats subjected to early stress and variable chronic stress during adulthood (#382)

Abstract

Neonatal maternal separation induces long-term alterations in the hypothalamicpituitary-adrenal axis and may increase vulnerability to depression when a stressful situation occurs in adulthood. Some studies, have found significant reductions in hippocampal volumes in patients with major depression. In contrast to other tricyclic antidepressants, tianeptine, a drug that increases serotonin reuptake, produces fewer side effects.