dc.contributor | Alcaraz, G. P. | |
dc.contributor.advisor | Oldano, Ana Verónica | |
dc.contributor.author | Aznar, Patricia Marcela | |
dc.date.accessioned | 2023-01-31T14:35:31Z | |
dc.date.issued | 2022-11-01 | |
dc.identifier.uri | http://hdl.handle.net/11086/30139 | |
dc.description | Trabajo Integrador Final (Especialista en Bioquímica Clínica Área Inmunología) - - Universidad Nacional de Córdoba. Facultad de Ciencias Químicas, 2022. | es |
dc.description.abstract | The SARS-COV-2 pandemic had an impact with more than 570 million cases and more than 6.8 million deaths as recorded by the United Nations by July 2022. Within the diagnostic context, a few immunological techniques for the detection of anti-SARS-CoV-2 IgG antibodies emerged, including Chemiluminescent Microparticle Immunoassay (CMIA) and Enzyme-Linked Immunosorbent Assay (ELISA). This study aimed to compare three detection techniques that have different methodological basis. The study was observational, cross-sectional and retrospective in design. Materials and methods: Serum samples were processed by the following methodologies: CMIA and “in-house” ELISA. Results: The methodologies were quantitatively evaluated by the correlation method, and qualitatively by assessing individual and simultaneous sensitivity and specificity. Conclusions: These methodologies were designed in a health emergency context so they do not have a gold standard; thus, different algorithms are proposed to improve both the sensitivity and specificity of the detection of SARS-CoV-2 antibodies. | es |
dc.language.iso | eng | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Anticuerpos | es |
dc.subject | Pruebas serológicas | es |
dc.subject | Pruebas de laboratorio | es |
dc.subject | Virus | es |
dc.subject | Covid 19 | es |
dc.subject | Métodos epidemiológicos | es |
dc.subject | Inmunología | es |
dc.title | Description and comparison of methods for the determination of anti-sars-COV-2 antibodies | es |
dc.type | doctoralThesis | es |
dc.description.embargo | 2024-10-31 | |
dc.description.fil | Fil: Aznar, Patricia Marcela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina. | es |
dc.description.fil | Fil: Aznar, Patricia Marcela. Tucumán. Gobierno de la Provincia de Tucumán. Ministerio de Salud. Laboratorio de Salud Pública. Sección Inmunología; Argentina. | es |