dc.contributor.author | Gilligan, Gerardo Marcelo | |
dc.contributor.author | Piemonte, Eduardo David | |
dc.contributor.author | Panico, René Luis | |
dc.contributor.author | Di Tada, Cecilia E. | |
dc.contributor.author | Brunotto, Mabel | |
dc.date.accessioned | 2022-04-06T14:03:44Z | |
dc.date.available | 2022-04-06T14:03:44Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://hdl.handle.net/11086/23671 | |
dc.description.abstract | Previous works of our team had shown clinical data which suggest that Chronic Mechanical Irritation (CMI) could be a risk factor for Oral Cancer (OC). However, there are no known patterns of biomarkers in CMI indicative of cellular malignancy. The aim of this study was to identify a biomarker pattern of differentiation (Ck19) and cell proliferation (Ki67) in CMI-associated lesions, similar to those observed in OC. Methods: a Cross-sectional study of adult patients (n = 61), both sexes, with lesions associated with CMI according to the Piemonte et al criteria. CK19 and Ki67 Immunohistochemistry were carried out in biopsies of both types of lesions and the patterns were described according to previous publications of Safadi and Argyris. The present study was approved by Ethics Committee of the College of Dentistry, Universidad Nacional de Cordoba. Results: Ki67 overexpression and a CK19 focal pattern with strong intensity in basal and parabasal cells were observed in CMI lesions, similar to that observed in OC. Conclusion: there is no scientific literature on biomarker patterns of Oral CMI. Therefore, the described pattern, particularly Ck19, is novel and could be indicative of the relationship between the presence of CMI and oral carcinogenesis. | es |
dc.format.medium | Impreso | |
dc.language.iso | eng | es |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Cáncer bucal | es |
dc.subject | Inflamación endodóntica | es |
dc.subject | Inmunohistoquímica | es |
dc.title | Oral carcinogenesis biomarkers in Oral Chronic Mechanical Irritation-associated lesions | es |
dc.type | conferenceObject | es |
dc.description.fil | Fil: Gilligan, Gerardo Marcelo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. | es |
dc.description.fil | Fil: Piemonte, Eduardo David. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. | es |
dc.description.fil | Fil: Panico, René Luis. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. | es |
dc.description.fil | Fil: Di Tada, Cecilia E. Fundación para el progreso de la Medicina; Argentina. | es |
dc.description.fil | Fil: Di Tada, Cecilia E.. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Química Biológica; Argentina. | es |
dc.description.fil | Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. | es |
dc.description.field | Otras Ciencias de la Salud | |
dc.conference.city | Río | |
dc.conference.country | Brasil | |
dc.conference.editorial | SOBEP | |
dc.conference.event | 44°congreso Sociedad Brasilera Estomatologia e Patología bucal | |
dc.conference.eventcity | Río | |
dc.conference.eventcountry | Brasil | |
dc.conference.eventdate | 2018-7 | |
dc.conference.institution | SOBEP | |
dc.conference.journal | SOBEP | |
dc.conference.publication | Libro | |
dc.conference.work | Resumen | |
dc.conference.type | Congreso | |