The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
Fecha
2021-05-08Autor
Blanco, Sebastián
Aguilar, Juan Javier
Konigheim, Brenda Salomé
Diaz, Luis Adrián
Spinsanti, Lorena
Beranek, Mauricio
Collino, César
Diaz, Miguel
Barbás, María Gabriela
Gallego, Sandra Verónica
Metadatos
Mostrar el registro completo del ítemResumen
Background: To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control.
Methods: We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with conrmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the rst week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection conrmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test.
Results: We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild–moderate disease.
Conclusion: The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.
Citación
Sebastián Blanco, Juan Javier Aguilar, Brenda Salomé Konigheim, Luis Adrian Diaz, Lorena Spinsanti, Mauricio Beranek, César Collino, Lab Central Córdoba working group, Miguel Diaz, María Gabriela Barbás, Sandra Verónica Gallego, The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort, Journal of Public Health, 2021;, fdab145, https://doi.org/10.1093/pubmed/fdab145
URI
http://hdl.handle.net/11086/20033https://academic.oup.com/jpubhealth/advance-article/doi/10.1093/pubmed/fdab145/6272006?searchresult=1
Colecciones
El ítem tiene asociados los siguientes ficheros de licencia: