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Sex differences in active DNA demethylation machinery during the critical period of brain masculinization
(2022)
In mammals, perinatal peaks in gonadal testosterone organize a sex-typical neural circuitry during sensitive periods of development and a growing body of evidence suggest that epigenetic mechanisms are implicated. Some of ...
Activation of erk1/2 and axogenesis induced by estradiol depend on different calcium pools in male rat hypothalamic neurons in vitro
(2016)
Estrogens generate a wide diversity of rapid “non-classical” effects which occur in a range from some seconds to few minutes (Arevalo et al., 2012), including the triggering of Ca2+ signals (Wong et al., 2012) and the ...
Sex differences in gene expression of X-linked histone demethylase Kdm6a in embryonic hypothalamic neurons
(2018)
Kdm6a and Kdm5c are histone demethylases that play an important role as epigenetic regulators of gene transcription by removing the di- and tri-methylation of Lys27 or Lys4 on histone H3 (H3K27me2/me3 - H3K4me2/me3). Both ...
Histone deacetylase gene expression is regulated by sex chromosome complement in the amygdala of the developing mouse brain
(2020)
Sexual differentiation of the rodent brain depends mainly on the action of androgens secreted by the fetal testis during the perinatal critical period (E17-P10). Recently, the role of genetic factors derived from sex ...
Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
(2014)
Developing brain of mammals is organized by gonadal steroids during the critical period of sexual differentiation (E18-PN10). The regulatory role of neurosteroids in the early brain is unclear. It is known that 17-β-estradiol ...
Role of sex chromosome complement in the regulation of aromatase expression in developing mice brain
(2016)
During the critical period of sexual differentiation there are sex differences in brain aromatase expression that are time and regionally specific. Some of these sex differences cannot be explained by
organizational — ...
Sex differences in GABA-mediated calcium influx in hypothalamic neurons
(2018)
GABAA receptor (GABAAR) activation exerts trophic actions in immature neurons through depolarization of resting membrane potential gating the opening of voltage-dependent calcium channels. Previous results from our lab ...
Sexual dimorphism in renal angiotensin receptors gene expression: sex chromosome complement involvement
(2016)
The process of biological sex differentiation involves genetic and hormonal developmental steps.
Clinical and basic findings indicate that the angiotensinergic system differentially regulates hydroelectrolyte and ...
Early sex differences in histone methyl transferase EZH2 expression in developing hypothalamus of the mouse brain
(2022)
In mammals, the primary agents causing phenotypic sex differences are encoded by sex chromosomes. Many of X-and Y-linked genes are epigenetic modifiers and pivotal evidence in past 7 years implicates epigenetic mechanisms ...
Role of X-linked genes on sex differences in neurogenin 3 expression in developing hypothalamic neurons
(2016)
Our previous findings indicate that sex chromosome complement regulates the generation of sex differences in mouse hypothalamic neuronal development. Higher expression of neurogenin 3 (Ngn3) in XX neurons mediates sex ...