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Distribution of genetic polymorphisms associated to hepatitis c virus (HCV) antiviral response in a multiethnic and admixed population
(2013-09)
Single-nucleotide polymorphisms (SNPs) near IL28B and ITPA genes have been described as predictors of response to antiviral treatment and ribavirin induced-hemolytic anemia in HCV patients, respectively. The prevalence of ...
Neuronal ceroid lipofuscinosis type cln2: prevalent phenotypes and genotypes in Latin America
(2013)
The Neuronal Ceroid Lipofuscinoses (NCLs), inherited neurodegenerative disorders, are the second most frequent group lysosomal pathologies (LP) of childhood. They are characterized by the pathological accumulation of ...
Combined effects of obesity, alcohol and smoking habit on semen quality of 2483 men attending an andrology clinic
(IVIRMA Global, IVIRMA Global, 2013)
Several factors have been identified as detrimental for sperm physiology (i.e. tobacco, alcohol, obesity, endocrine disruptors, etc); however, none of them can justify seminal decline by itself.
Therefore, the objective ...
Genetic defects in the liver phosphorylase system in Argentine patients nosological definition through a strategy of enzimatic and molecular analysis
(Universidad Nacional de Córdoba. Facultad de Ciencias Médicas., 2013)
The phosphorylase and phosphorylase-b kinase (PHK) deficiencies in the liver constitute the phosphorylase system defects (PSD), leading to Glycogenosis Type VI (GSD-VI) and Type IX (GSD-IX), respectively. The hepatic ...
Nonsense mediated mRNA decay affects nonsense transcripts levelsand in vitro response to gentamicin and ataluren in X-ALD
(2013)
Background: X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene, characterized by increased concentrations of very long-chain fatty acids due to a defect in peroxisomal β-oxidation. ...
Downregulation of GLI1- dependent survival pathway underlies arachidonic acid antitumoral activity
(Argentine Society for biochemistry and molecular biology research, 2013)
Numerous studies have demonstrated a role for essential fatty acids (ePUFAs) during tumor evelopment. However, the molecularmechanism underlying this phenomenon remains elusive. Here, we defined a novel molecular mechanism ...
Intrahipotalamic ghrelin administration decreases sperm concentration and motility in mice
(Universidad Nacional de Córdoba, 2013)
Ghrelin (Ghr) is a peptide secreted primarily in the stomach and hypothalamus. However, Ghr and its receptors are synthesized also in many tissues of the reproductive tract. In situations of hiperghrelinemia (fasting or ...
Cochlear implant in far advanced otosclerosis. Performance complications-long term results
(Grupo Iberoamericano de Implantes Cocleares y Ciencias afines (GICCA), 2013-04)
Patients with far advanced otosclerosis demonstrated good performance with CI in 26/32 cases. In the cases with otosclerosis type 3, 5/6 patients had more difficulty in the insertion of electrodes, 1 of them with 2 electrodes ...
Ultrastructure of human autologous macrophage lymphocyte rosettes in Chagas disease
(International Union of Immunological Societies (IUIS), International Union of Immunological Societies (IUIS), 2013)
The processing and antigen presentation are involved in human macrophage lymphocyte rosette (MLR) and in this phenomenon of multiple immune synapse (IS) the autologous antigens of senescent neutrophils are presented by ...
Implications of oxidative stress and placental structural alterations in Trypanosoma cruzi infection in vitro and ex vivo
(V Latin American Symposium on Maternal Fetal Interaction & Placenta, 2013)
Human placenta participates in the control of Chagas congenital infection, which could be due by nitric oxide synthase (NOS) and peroxinitrites which are deleterious for Trypanosoma cruzi and placental tissue. We proposed ...